Novel Dopamine D2 Receptor Antagonists and Methods of Their Use
Investigators at the NIH have identified a series of novel, small molecule antagonists of the dopamine D2 receptor. Among the dopamine receptor (DAR) subtypes, D2 DAR is arguably one of the most...
View ArticlePrevention or Treatment of Viral Infections by Inhibition of the Histone...
Herpes simplex viral infections, including herpes simplex virus type 1 (HSV-1) and type 2 (HSV-2), are exceptionally common worldwide. These viruses establish lifelong persistent infections with cycles...
View ArticleMouse Model for Study of Diabetic Nephropathy and Role of Soluble Epoxide...
Diabetic nephropathy (DN) is the leading cause of renal failure and is characterized by proteinuria that progresses to renal inflammation and decline in the glornerular filtration barrier (GFB)....
View ArticleMice with a Floxed Allele of the alpha Subunit of the Heterotrimeric G...
Heterotrimeric G proteins couple signals between GPCRs (G protein coupled receptors) and effectors such as adenylyl cyclase, phospholipase C and ion channels. Among the G proteins are Go and Gi2. Go is...
View ArticleTRPC Knockout (KO) Mice and Mice with a Floxed Allele of TRPC Ion Channel Genes
TRPCs (Canonical Transient Receptor Potential Channels) are a group of non-selective cation channels that allow sodium and calcium into cells. There are seven different genes in mice that code TRPCs....
View ArticleThalidomide Analogs that Inhibit Inflammation and Angiogenesis
Thalidomide and its close analogs (lenalidomide and pomalidomide) are widely used to treat a variety of diseases, such as multiple myeloma and other cancers as well as the symptoms of several...
View ArticleLong Acting Therapeutic Conjugates with Evans Blue
This invention is a platform technology that pertains to the advantages of conjugating therapeutics to Evans Blue thus providing long lasting pharmacokinetic profiles by complexing with albumin....
View ArticleTriazole Derivatives of 4,7-disubstituted 2 naphthoic acid (PPTN) as P2Y14...
The Molecular Recognition Section of NIDDK announces the availability of a novel triazole-based probes, structures which act as antagonists at human P2Y14 receptors. Although the physiologic functions...
View ArticleMethods of Making and Using Dopamine D3 Receptor Selective...
Dopamine is a major neurotransmitter in the central nervous system and among other functions is directly related to the rewarding effects of drugs of abuse. Dopamine signaling is mediated by D1, D2,...
View ArticleLRRK2 Inhibitors: Novel Treatment for Intestinal Bowel Disorders
Use of Leucine Rich Repeat Kinase 2 (LRRK2) inhibitors for the treatment of Intestinal Bowel Disorders (IBD) is disclosed. IBD is a broad term that describes conditions with chronic or recurring immune...
View ArticlePotential New Drugs for Treating or Preventing Pruritus
NIH scientists have identified new compositions that could potentially be used to treat or prevent pruritus (itchiness). The newly discovered compounds can block a newly identified itch pathway and...
View ArticleNovel Peptide of Streptococcus pneumoniae Surface Adhesion A (PsaA) Protein...
Streptococcus pneumoniae (S. pneumonia), bacteria commonly referred to as pneumococcus, are a significant cause of disease resulting in 1.5 million deaths every year worldwide according to the World...
View ArticleAntibodies for Rabies Post-exposure Prophylaxis or Antiviral Therapy of...
Lyssaviruses are single-stranded RNA viruses that cause rabies and rabies-like diseases in mammals. According to the World Health Organization, human rabies caused by the classical rabies virus...
View ArticleHeterocyclic Compounds for the Treatment of Hepatitis C Virus
The vast majority of people infected with Hepatitis C Virus (HCV) will have chronic infection. Over decades, this can lead to liver disease and liver cancer. In fact, HCV infection is the leading cause...
View ArticlePotential Treatment for sickle-cell disease and thalassemia
The technology addresses treatment options for diseases such as sickle-cell and thalassemia. Traditionally, such beta-globinopathies are treated through bone marrow transplantation. However, this...
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